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Symptomatic CNS metastases OR superior vena cava (SVC) syndrome OR rapid radiographic pro...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDRF-NSCLC-TRANSFORMATION-PROGRESSION
TypeRed flag
Statuspending_clinical_signoff
DiseasesDIS-NSCLC
SourcesSRC-ESMO-NSCLC-METASTATIC-2024 SRC-NCCN-NSCLC-2025

Red Flag Origin

DefinitionSymptomatic CNS metastases OR superior vena cava (SVC) syndrome OR rapid radiographic progression on therapy — emergency / aggressive-progression flag requiring brain imaging, RT/surgical consult, and treatment intensification or sequencing change.
Clinical directionhold
Categorytransformation-progression

Trigger Logic

{
  "any_of": [
    {
      "finding": "symptomatic_cns_metastases",
      "value": true
    },
    {
      "finding": "svc_syndrome",
      "value": true
    },
    {
      "finding": "rapid_radiographic_progression_nsclc",
      "value": true
    }
  ],
  "type": "composite_clinical"
}

Notes

CNS-active TKI options critical for ALK / EGFR / ROS1 mets — alectinib / lorlatinib / brigatinib / osimertinib all have CNS efficacy. SVC syndrome: emergent RT or stenting; systemic therapy proceeds in parallel.

Used By

Algorithms

Indications