Active TB OR latent TB conversion risk — ICI may trigger TB reactivation; pre-treatment I...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-NSCLC-INFECTION-SCREENING`
Type	Red flag
Status	pending_clinical_signoff
Diseases	`DIS-NSCLC`
Sources	`SRC-ESMO-NSCLC-METASTATIC-2024` `SRC-NCCN-NSCLC-2025`

Red Flag Origin

Definition	Active TB OR latent TB conversion risk — ICI may trigger TB reactivation; pre-treatment IGRA / TST + chest imaging recommended.
Clinical direction	hold
Category	infection-screening

Trigger Logic

{
  "any_of": [
    {
      "finding": "tb_latent",
      "value": "positive"
    },
    {
      "finding": "tb_active",
      "value": true
    }
  ],
  "type": "composite_clinical"
}

Notes

Ukraine is an HBV/HCV/TB high-prevalence region — pre-ICI screen more important than in low-prevalence settings. HBV reactivation risk handled by RF-UNIVERSAL-HBV-REACTIVATION-RISK.

Used By

Indications

IND-MESOTHELIOMA-1L-NIVO-IPI - IND-MESOTHELIOMA-1L-NIVO-IPI
IND-MESOTHELIOMA-2L-NIVO - IND-MESOTHELIOMA-2L-NIVO