Histologic transformation to DLBCL (already wired through RF-FL-TRANSFORMATION-SUSPECT in...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-NMZL-TRANSFORMATION-PROGRESSION`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-NODAL-MZL`
Sources	`SRC-ESMO-MZL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Histologic transformation to DLBCL (already wired through RF-FL-TRANSFORMATION-SUSPECT in ALGO-NMZL-1L) — biopsy-confirmed transformation reclassifies as DLBCL pathway.
Clinical direction	intensify
Category	transformation-progression

Trigger Logic

{
  "any_of": [
    {
      "finding": "biopsy_shows_dlbcl",
      "value": true
    },
    {
      "finding": "nmzl_transformation_suspected",
      "value": true
    }
  ],
  "type": "composite_clinical"
}

Notes

ALGO-NMZL-1L already imports RF-FL-TRANSFORMATION-SUSPECT; this NMZL-specific entry duplicates that semantically. Kept distinct for MDT-brief disease-context labeling.

Used By

Algorithms

ALGO-NMZL-2L - ALGO-NMZL-2L