Renal dysfunction (CrCl <40 mL/min) — bendamustine clearance reduced; dose adjustment or...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-NMZL-ORGAN-DYSFUNCTION`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-NODAL-MZL`
Sources	`SRC-ESMO-MZL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Renal dysfunction (CrCl <40 mL/min) — bendamustine clearance reduced; dose adjustment or alternative regimen (R-CHOP or rituximab monotherapy) considered.
Clinical direction	investigate
Category	organ-dysfunction

Trigger Logic

{
  "any_of": [
    {
      "comparator": "<",
      "finding": "creatinine_clearance_ml_min",
      "threshold": 40
    }
  ],
  "type": "lab_value"
}

Notes

Bendamustine renally cleared; dose reduce 25-50% if CrCl 30-50 mL/min, avoid <30 mL/min.

Used By

Algorithms

ALGO-NMZL-2L - ALGO-NMZL-2L