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Age >80 OR ECOG ≥3 with comorbidity AND asymptomatic NMZL (no GELF criteria) — observatio...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDRF-NMZL-FRAILTY-AGE
TypeRed flag
Statusreviewed 2026-04-25 | pending_clinical_signoff
DiseasesDIS-NODAL-MZL
SourcesSRC-ESMO-MZL-2024 SRC-NCCN-BCELL-2025

Red Flag Origin

DefinitionAge >80 OR ECOG ≥3 with comorbidity AND asymptomatic NMZL (no GELF criteria) — observation appropriate; rituximab monotherapy if treatment indicated.
Clinical directionde-escalate
Categoryfrailty-age

Trigger Logic

{
  "all_of": [
    {
      "finding": "nmzl_asymptomatic",
      "value": true
    },
    {
      "any_of": [
        {
          "comparator": ">",
          "finding": "age_years",
          "threshold": 80
        },
        {
          "all_of": [
            {
              "comparator": ">=",
              "finding": "ecog_status",
              "threshold": 3
            },
            {
              "comparator": ">=",
              "finding": "comorbidity_count",
              "threshold": 2
            }
          ]
        }
      ]
    }
  ],
  "type": "composite_clinical"
}

Notes

NMZL is indolent like FL; watch-and-wait standard for asymptomatic. Active treatment reserved for symptomatic burden.

Used By

Algorithms