Pulmonary or cardiac dysfunction in field-of-RT region — radiation contraindicated; ritux...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-NLPBL-ORGAN-DYSFUNCTION`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-NLPBL`
Sources	`SRC-ESMO-HODGKIN-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Pulmonary or cardiac dysfunction in field-of-RT region — radiation contraindicated; rituximab monotherapy or systemic chemo alternative.
Clinical direction	de-escalate
Category	organ-dysfunction

Trigger Logic

{
  "any_of": [
    {
      "finding": "pulmonary_dysfunction_rt_field",
      "value": true
    },
    {
      "finding": "cardiac_dysfunction_rt_field",
      "value": true
    },
    {
      "comparator": "<",
      "finding": "lvef_percent",
      "threshold": 50
    }
  ],
  "type": "composite_clinical"
}

Notes

NLPBL is highly responsive to RT; field-of-RT organ dysfunction is the main contraindication. Rituximab monotherapy + observation acceptable alternative.

Used By

No reverse references found in the YAML corpus.