Variant histology (T-cell rich, diffuse, or with histologic transformation to DLBCL/THRLB...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-NLPBL-HIGH-RISK-BIOLOGY`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-NLPBL`
Sources	`SRC-ESMO-HODGKIN-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Variant histology (T-cell rich, diffuse, or with histologic transformation to DLBCL/THRLBCL) — distinct from classical NLPBL nodular pattern; standard NLPBL approach inadequate, treat as aggressive B-cell lymphoma (R-CHOP-based).
Clinical direction	intensify
Category	high-risk-biology

Trigger Logic

{
  "any_of": [
    {
      "finding": "nlpbl_variant_histology",
      "value": true
    },
    {
      "finding": "thrlbcl_pattern",
      "value": true
    },
    {
      "finding": "biopsy_shows_dlbcl",
      "value": true
    }
  ],
  "type": "biomarker"
}

Notes

Variant pattern NLPBL behaves like aggressive B-cell lymphoma; reclassification to DLBCL pathway expected.

Used By

No reverse references found in the YAML corpus.