Age >75 + ECOG ≥3 with asymptomatic stage I-II disease — observation alone is appropriate...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-NLPBL-FRAILTY-AGE`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-NLPBL`
Sources	`SRC-ESMO-HODGKIN-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Age >75 + ECOG ≥3 with asymptomatic stage I-II disease — observation alone is appropriate (NLPBL indolent natural history); RT spared.
Clinical direction	de-escalate
Category	frailty-age

Trigger Logic

{
  "all_of": [
    {
      "finding": "nlpbl_stage_i_or_ii",
      "value": true
    },
    {
      "finding": "nlpbl_asymptomatic",
      "value": true
    },
    {
      "any_of": [
        {
          "comparator": ">",
          "finding": "age_years",
          "threshold": 75
        },
        {
          "comparator": ">=",
          "finding": "ecog_status",
          "threshold": 3
        }
      ]
    }
  ],
  "type": "composite_clinical"
}

Notes

NLPBL has near-normal life expectancy in indolent forms; treatment de-escalation prioritized in elderly.

Used By

Indications

IND-NLPBL-2L-RCHOP-TRANSFORMATION - IND-NLPBL-2L-RCHOP-TRANSFORMATION