EBV plasma DNA quantification at baseline + during treatment — high baseline EBV (>10^4 c...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-NK-T-NASAL-INFECTION-SCREENING`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-NK-T-NASAL`
Sources	`SRC-ESMO-PTCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	EBV plasma DNA quantification at baseline + during treatment — high baseline EBV (>10^4 copies/mL) and persistent EBV-positivity post-induction predict worse outcomes.
Clinical direction	investigate
Category	infection-screening

Trigger Logic

{
  "any_of": [
    {
      "comparator": ">=",
      "finding": "ebv_dna_copies_per_ml",
      "threshold": 10000
    },
    {
      "finding": "ebv_persistent_post_induction",
      "value": true
    }
  ],
  "type": "biomarker"
}

Notes

EBV DNA tracking is THE biomarker of response in NK/T-nasal. Drives intensification of consolidation and surveillance schedule.

Used By

No reverse references found in the YAML corpus.