Age >65 OR ECOG ≥3 — SMILE myelosuppression intolerable; modified DDGP or AspaMetDex with...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-NK-T-NASAL-FRAILTY-AGE`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-NK-T-NASAL`
Sources	`SRC-ESMO-PTCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Age >65 OR ECOG ≥3 — SMILE myelosuppression intolerable; modified DDGP or AspaMetDex with reduced asparaginase dosing acceptable.
Clinical direction	de-escalate
Category	frailty-age

Trigger Logic

{
  "any_of": [
    {
      "comparator": ">",
      "finding": "age_years",
      "threshold": 65
    },
    {
      "comparator": ">=",
      "finding": "ecog_status",
      "threshold": 3
    }
  ],
  "type": "composite_clinical"
}

Notes

SMILE TRM in elderly is high (10-15%); reduced-intensity regimens trade 5-10% efficacy for tolerability.

Used By

No reverse references found in the YAML corpus.