Symptomatic CNS metastases — ICI doublet (nivo+ipi) intracranially active; BRAFi+MEKi for...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-MELANOMA-TRANSFORMATION-PROGRESSION`
Type	Red flag
Status	pending_clinical_signoff
Diseases	`DIS-MELANOMA`
Sources	`SRC-ESMO-MELANOMA-2024` `SRC-NCCN-MELANOMA-2025`

Red Flag Origin

Definition	Symptomatic CNS metastases — ICI doublet (nivo+ipi) intracranially active; BRAFi+MEKi for visceral crisis.
Clinical direction	intensify
Category	transformation-progression

{
  "any_of": [
    {
      "finding": "symptomatic_cns_metastases",
      "value": true
    }
  ],
  "type": "composite_clinical"
}

CheckMate-204: nivo+ipi ICR ~46% in active brain mets.