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LDH >2x ULN OR severe hepatic dysfunction — predictor of inferior ICI outcomes.

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDRF-MELANOMA-ORGAN-DYSFUNCTION
TypeRed flag
Statuspending_clinical_signoff
DiseasesDIS-MELANOMA
SourcesSRC-ESMO-MELANOMA-2024 SRC-NCCN-MELANOMA-2025

Red Flag Origin

DefinitionLDH >2x ULN OR severe hepatic dysfunction — predictor of inferior ICI outcomes.
Clinical directioninvestigate
Categoryorgan-dysfunction

Trigger Logic

{
  "any_of": [
    {
      "comparator": ">",
      "finding": "ldh_x_uln",
      "threshold": 2
    },
    {
      "finding": "child_pugh_class",
      "value": "C"
    }
  ],
  "type": "lab_value"
}

Notes

LDH integral AJCC staging variable.

Used By

Indications