Refractory or rapid-relapse disease post-ICE — alloSCT urgently if not yet planned; other...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-HSTCL-TRANSFORMATION-PROGRESSION`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-HSTCL`
Sources	`SRC-ESMO-PTCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Refractory or rapid-relapse disease post-ICE — alloSCT urgently if not yet planned; otherwise pralatrexate or romidepsin salvage with transplant intent.
Clinical direction	investigate
Category	transformation-progression

Trigger Logic

{
  "any_of": [
    {
      "finding": "hstcl_refractory_post_ice",
      "value": true
    },
    {
      "finding": "hstcl_rapid_relapse",
      "value": true
    }
  ],
  "type": "composite_clinical"
}

Notes

HSTCL refractory disease has very poor outcomes; alloSCT is the only realistic curative path.

Used By

No reverse references found in the YAML corpus.