EBV / HBV / HCV / CMV / Strongyloides screen pre-induction; HSTCL is rare in immunocompet...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-HSTCL-INFECTION-SCREENING`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-HSTCL`
Sources	`SRC-ESMO-PTCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	EBV / HBV / HCV / CMV / Strongyloides screen pre-induction; HSTCL is rare in immunocompetent — exclude post-transplant or anti-TNF-driven HSTCL (different etiology, may regress with IS-reduction).
Clinical direction	investigate
Category	infection-screening

Trigger Logic

{
  "any_of": [
    {
      "finding": "hbsag",
      "value": "positive"
    },
    {
      "finding": "ebv_pcr_blood_positive",
      "value": true
    },
    {
      "finding": "post_transplant_setting",
      "value": true
    },
    {
      "finding": "anti_tnf_exposure",
      "value": true
    }
  ],
  "type": "composite_clinical"
}

Notes

Anti-TNF-induced HSTCL (Crohn's IBD patients) sometimes regresses with TNF-inhibitor withdrawal; PTLD-like HSTCL after solid organ transplant follows different paradigm. Etiology drives initial path.

Used By

No reverse references found in the YAML corpus.