γδ T-cell receptor variant (most common) vs αβ variant — both aggressive but γδ classical...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-HSTCL-HIGH-RISK-BIOLOGY`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-HSTCL`
Sources	`SRC-ESMO-PTCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	γδ T-cell receptor variant (most common) vs αβ variant — both aggressive but γδ classically associated with worse prognosis; SETD2/INO80 mutations confer chemo-resistance.
Clinical direction	intensify
Category	high-risk-biology

Trigger Logic

{
  "any_of": [
    {
      "finding": "tcr_gamma_delta_phenotype",
      "value": true
    },
    {
      "finding": "setd2_mutation",
      "value": true
    },
    {
      "finding": "ino80_mutation",
      "value": true
    }
  ],
  "type": "biomarker"
}

Notes

HSTCL biology drives early alloSCT decision more than 1L regimen choice (ICE is universal default). Flag MDT-priority for transplant referral.

Used By

No reverse references found in the YAML corpus.