Cardiac dysfunction (LVEF <50%) — DA-EPOCH-R (preferred for HGBL-DH/-TH) is anthracycline...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-HGBL-DH-ORGAN-DYSFUNCTION`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-HGBL-DH`
Sources	`SRC-ESMO-DLBCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Cardiac dysfunction (LVEF <50%) — DA-EPOCH-R (preferred for HGBL-DH/-TH) is anthracycline-intensive; cardio-onc consult and dose-modification required.
Clinical direction	investigate
Category	organ-dysfunction

Trigger Logic

{
  "any_of": [
    {
      "comparator": "<",
      "finding": "lvef_percent",
      "threshold": 50
    }
  ],
  "type": "lab_value"
}

Notes

DA-EPOCH-R cumulative doxorubicin exceeds R-CHOP; cardio-monitoring should be aggressive in baseline-borderline LVEF. Indication-level dose adjustment, not 1L Algorithm shift.

Used By

Algorithms

ALGO-HGBL-DH-2L - ALGO-HGBL-DH-2L