HBV/HCV/HIV serology mandatory pre-rituximab; HIV-associated HGBL-DH gets cART optimizati...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-HGBL-DH-INFECTION-SCREENING`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-HGBL-DH`
Sources	`SRC-ESMO-DLBCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	HBV/HCV/HIV serology mandatory pre-rituximab; HIV-associated HGBL-DH gets cART optimization concurrently with chemo.
Clinical direction	investigate
Category	infection-screening

Trigger Logic

{
  "any_of": [
    {
      "finding": "hbsag",
      "value": "positive"
    },
    {
      "finding": "anti_hcv",
      "value": "positive"
    },
    {
      "finding": "hiv_serology",
      "value": "positive"
    }
  ],
  "type": "biomarker"
}

Notes

Cross-disease HBV reactivation by RF-UNIVERSAL-HBV-REACTIVATION-RISK. HIV-HGBL behaves more aggressively but treatment intent unchanged.

Used By

Algorithms

ALGO-HGBL-DH-2L - ALGO-HGBL-DH-2L