Age >75 OR ECOG ≥3 — DA-EPOCH-R toxicity prohibitive; modified R-CHOP + IT MTX prophylaxi...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-HGBL-DH-FRAILTY-AGE`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-HGBL-DH`
Sources	`SRC-ESMO-DLBCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Age >75 OR ECOG ≥3 — DA-EPOCH-R toxicity prohibitive; modified R-CHOP + IT MTX prophylaxis acceptable compromise.
Clinical direction	de-escalate
Category	frailty-age

Trigger Logic

{
  "any_of": [
    {
      "comparator": ">",
      "finding": "age_years",
      "threshold": 75
    },
    {
      "comparator": ">=",
      "finding": "ecog_status",
      "threshold": 3
    }
  ],
  "type": "composite_clinical"
}

Notes

DA-EPOCH-R toxicity in elderly approaches 25-30% treatment-related mortality; modified R-CHOP retains majority of efficacy with manageable toxicity. Decision sits at Indication-dose level.

Age >75 OR ECOG ≥3 — DA-EPOCH-R toxicity prohibitive; modified R-CHOP + IT MTX prophylaxi...

Red Flag Origin

Trigger Logic

Notes

Used By

Algorithms

Indications