Renal dysfunction (CrCl <60 mL/min) — cladribine clearance reduced; dose adjustment or pe...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-HCL-ORGAN-DYSFUNCTION`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-HCL`
Sources	`SRC-ESMO-DLBCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Renal dysfunction (CrCl <60 mL/min) — cladribine clearance reduced; dose adjustment or pentostatin alternative considered.
Clinical direction	investigate
Category	organ-dysfunction

Trigger Logic

{
  "any_of": [
    {
      "comparator": "<",
      "finding": "creatinine_clearance_ml_min",
      "threshold": 60
    }
  ],
  "type": "lab_value"
}

Notes

Both cladribine and pentostatin are renally cleared; CrCl <60 mL/min triggers 25-50% dose reduction. Hematology decision; not a regimen-class shift.

Used By

Algorithms

ALGO-HCL-2L - ALGO-HCL-2L