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Age >75 + ECOG ≥2 OR significant comorbidity — pentostatin's weekly schedule allows finer...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

Red Flag Origin

Trigger Logic

{
  "all_of": [
    {
      "any_of": [
        {
          "comparator": ">",
          "finding": "age_years",
          "threshold": 75
        },
        {
          "comparator": ">=",
          "finding": "comorbidity_count",
          "threshold": 2
        }
      ]
    },
    {
      "comparator": ">=",
      "finding": "ecog_status",
      "threshold": 2
    }
  ],
  "type": "composite_clinical"
}

Notes

Pentostatin's weekly cadence permits adjustment between doses; cladribine's 5-7-day infusion is committed. For elderly frail, pentostatin's tolerability advantage outweighs cladribine's slightly higher CR rate.

Used By

Algorithms

• ALGO-HCL-1L - ALGO-HCL-1L
• ALGO-HCL-2L - ALGO-HCL-2L

Indications

• IND-HCL-2L-VEMURAFENIB - IND-HCL-2L-VEMURAFENIB