Sarcomatoid transformation OR carcinosarcoma — distinct biology requiring different chemo...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-ENDOMETRIAL-TRANSFORMATION-PROGRESSION`
Type	Red flag
Status	pending_clinical_signoff
Diseases	`DIS-ENDOMETRIAL`
Sources	`SRC-ESMO-ENDOMETRIAL-2022` `SRC-NCCN-UTERINE-2025`

Red Flag Origin

Definition	Sarcomatoid transformation OR carcinosarcoma — distinct biology requiring different chemo backbone.
Clinical direction	intensify
Category	transformation-progression

Trigger Logic

{
  "any_of": [
    {
      "finding": "endometrial_carcinosarcoma",
      "value": true
    },
    {
      "finding": "endometrial_sarcomatoid",
      "value": true
    }
  ],
  "type": "composite_clinical"
}

Notes

Carcinosarcoma: ifos-paclitaxel historical.

Used By

Indications

IND-ENDOMETRIAL-STAGE-I-POLE-OBSERVATION - IND-ENDOMETRIAL-STAGE-I-POLE-OBSERVATION