Cardiac dysfunction (LVEF <50%) — limits anthracycline OR trastuzumab (HER2+ serous varia...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-ENDOMETRIAL-ORGAN-DYSFUNCTION`
Type	Red flag
Status	pending_clinical_signoff
Diseases	`DIS-ENDOMETRIAL`
Sources	`SRC-ESMO-ENDOMETRIAL-2022` `SRC-NCCN-UTERINE-2025`

Red Flag Origin

Definition	Cardiac dysfunction (LVEF <50%) — limits anthracycline OR trastuzumab (HER2+ serous variant).
Clinical direction	investigate
Category	organ-dysfunction

{
  "any_of": [
    {
      "comparator": "<",
      "finding": "lvef_percent",
      "threshold": 50
    }
  ],
  "type": "lab_value"
}

HER2+ serous endometrial subset eligible for trastuzumab + chemo.

IND-ENDOMETRIAL-2L-DOSTARLIMAB-DMMR - IND-ENDOMETRIAL-2L-DOSTARLIMAB-DMMR
IND-ENDOMETRIAL-2L-PEMBRO-LENVA-PMMR - IND-ENDOMETRIAL-2L-PEMBRO-LENVA-PMMR
IND-ENDOMETRIAL-STAGE-I-POLE-OBSERVATION - IND-ENDOMETRIAL-STAGE-I-POLE-OBSERVATION