dMMR/MSI-high OR p53-abnormal OR POLE-mutated — TCGA classification drives ICI eligibilit...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-ENDOMETRIAL-HIGH-RISK-BIOLOGY`
Type	Red flag
Status	pending_clinical_signoff
Diseases	`DIS-ENDOMETRIAL`
Sources	`SRC-ESMO-ENDOMETRIAL-2022` `SRC-NCCN-UTERINE-2025`

Red Flag Origin

Definition	dMMR/MSI-high OR p53-abnormal OR POLE-mutated — TCGA classification drives ICI eligibility.
Clinical direction	intensify
Category	high-risk-biology

Trigger Logic

{
  "any_of": [
    {
      "finding": "BIO-DMMR-IHC",
      "value": "deficient"
    },
    {
      "finding": "BIO-MSI-STATUS",
      "value": "high"
    },
    {
      "finding": "p53_abnormal",
      "value": true
    },
    {
      "finding": "pole_mutation",
      "value": true
    }
  ],
  "type": "biomarker"
}

Notes

Universal molecular profiling. dMMR triggers Lynch screening.

Used By

Indications

IND-ENDOMETRIAL-STAGE-I-POLE-OBSERVATION - IND-ENDOMETRIAL-STAGE-I-POLE-OBSERVATION