Type II EATL (monomorphic epitheliotropic intestinal T-cell lymphoma) per WHO classificat...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-EATL-HIGH-RISK-BIOLOGY`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-EATL`
Sources	`SRC-ESMO-PTCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Type II EATL (monomorphic epitheliotropic intestinal T-cell lymphoma) per WHO classification — distinct from celiac-associated Type I EATL; often non-celiac, more chemo-refractory.
Clinical direction	intensify
Category	high-risk-biology

Trigger Logic

{
  "any_of": [
    {
      "finding": "eatl_type_ii_meitl",
      "value": true
    },
    {
      "finding": "celiac_disease_negative_eatl",
      "value": true
    }
  ],
  "type": "biomarker"
}

Notes

Type II EATL (now MEITL in WHO 2022) has worse outcomes than Type I; intensification options limited (alloSCT considered upfront when feasible).

Used By

No reverse references found in the YAML corpus.