IDH1 R132 mutation in intrahepatic cholangiocarcinoma after progression on gemcitabine/ci...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-CHOLANGIO-IDH1-R132-ACTIONABLE`
Type	Red flag
Status	reviewed 2026-05-07 \| pending_clinical_signoff
Diseases	`DIS-CHOLANGIOCARCINOMA`
Sources	`SRC-ESMO-BTC-2023` `SRC-FIGHT-202` `SRC-NCCN-HEPATOBILIARY`

Red Flag Origin

Definition	IDH1 R132 mutation in intrahepatic cholangiocarcinoma after progression on gemcitabine/cisplatin-based therapy. Routes 2L targeted therapy review toward ivosidenib.
Clinical direction	intensify
Category	high-risk-biology
Shifts algorithm	ALGO-CHOLANGIO-2L

Trigger Logic

{
  "any_of": [
    {
      "finding": "idh1_r132_mutation",
      "value": true
    },
    {
      "finding": "idh1_status",
      "value": "R132"
    },
    {
      "finding": "IDH1",
      "value": "R132C"
    },
    {
      "finding": "BIO-IDH1-MUTATION",
      "value": "R132C"
    }
  ],
  "type": "biomarker"
}

Used By

Algorithms

ALGO-CHOLANGIO-2L - ALGO-CHOLANGIO-2L