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Age ≥65 OR ECOG ≥3 with comorbidities — pediatric-inspired regimens (CALGB 10403, hyper-C...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

Red Flag Origin

Trigger Logic

{
  "any_of": [
    {
      "comparator": ">=",
      "finding": "age_years",
      "threshold": 65
    },
    {
      "all_of": [
        {
          "comparator": ">=",
          "finding": "ecog_status",
          "threshold": 3
        },
        {
          "comparator": ">=",
          "finding": "comorbidity_count",
          "threshold": 2
        }
      ]
    }
  ],
  "type": "composite_clinical"
}

Notes

Pediatric-inspired adolescent-young-adult protocols dominate in fit <40; >65 mortality from induction toxicity is high. Mini-HCVD + inotuzumab/blinatumomab achieves better tolerability with comparable CR rates.

Used By

Algorithms

• ALGO-B-ALL-2L - ALGO-B-ALL-2L

Indications

• IND-B-ALL-2L-INOTUZUMAB - IND-B-ALL-2L-INOTUZUMAB