HTLV-1 confirmation by serology + PCR; Strongyloides screen mandatory (HTLV-1 endemic are...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-ATLL-INFECTION-SCREENING`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-ATLL`
Sources	`SRC-ESMO-PTCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	HTLV-1 confirmation by serology + PCR; Strongyloides screen mandatory (HTLV-1 endemic areas); HBV/HCV/HIV pre-treatment.
Clinical direction	investigate
Category	infection-screening

Trigger Logic

{
  "any_of": [
    {
      "finding": "htlv1_serology",
      "value": "positive"
    },
    {
      "finding": "strongyloides_endemic_exposure",
      "value": true
    }
  ],
  "type": "biomarker"
}

Notes

HTLV-1 confirmation is part of diagnosis; Strongyloides hyperinfection mortality post-immunosuppression is high in endemic-area exposure.

Used By

Algorithms

ALGO-ATLL-1L - ALGO-ATLL-1L