Age >70 + ECOG ≥3 OR severe cytopenia at diagnosis — mLSG-15 intensive chemotherapy exces...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-ATLL-FRAILTY-AGE`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-ATLL`
Sources	`SRC-ESMO-PTCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Age >70 + ECOG ≥3 OR severe cytopenia at diagnosis — mLSG-15 intensive chemotherapy excessive toxicity; CHOP-based or AZT+IFN-α (even in aggressive subtype) considered.
Clinical direction	de-escalate
Category	frailty-age

Trigger Logic

{
  "all_of": [
    {
      "comparator": ">=",
      "finding": "ecog_status",
      "threshold": 3
    },
    {
      "comparator": ">",
      "finding": "age_years",
      "threshold": 70
    }
  ],
  "type": "composite_clinical"
}

Notes

ATLL endemic in older Japanese/Caribbean populations; mLSG-15 trials excluded >70. Real-world elderly aggressive ATLL often gets dose-reduced CHOP at best.

Used By

No reverse references found in the YAML corpus.