Multiple Myeloma · line 1 · Bortezomib + Lenalidomide + Dexamethasone (VRd), 4-6 induction cycles
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
Knowledge-base record for audit. Provisional clinical content: this is not a prescription. An oncologist must verify original sources, applicability and review status. Full rules and constraints are in the YAML.
| Line of therapy | 1 |
|---|---|
| Track | standard |
| Linked regimen | REG-VRD |
| ID | IND-MM-1L-VRD |
|---|---|
| Type | Indication |
| Status | reviewed 2026-04-25 | pending_clinical_signoff |
| Diseases | DIS-MM |
| Sources | SRC-NCCN-MM-2025 |
Notes
STUB — requires clinical co-lead signoff before publication. Standard track for the MM 1L two-plan output (CHARTER §2). Transplant eligibility is assessed separately and shapes total cycle count + post-induction pathway, but does not change the induction regimen at this layer.
Used By
Algorithms
ALGO-MM-1L- ALGO-MM-1L
Contraindications
CI-BORTEZOMIB-SEVERE-NEUROPATHY- CI-BORTEZOMIB-SEVERE-NEUROPATHYCI-LENALIDOMIDE-PREGNANCY- CI-LENALIDOMIDE-PREGNANCY
Handbook Chapters
HB-MM-1L- Multiple myeloma: first-line risk and fitness reasoning
Handbook Questions
HQ-MM-1L-003- HQ-MM-1L-003
Indication
IND-MM-1L-DVRD- IND-MM-1L-DVRDIND-MM-1L-RD- IND-MM-1L-RD
Red flag
RF-MM-FRAILTY-AGE- Frailty profile precluding standard-dose VRd / D-VRd induction in MM: IMWG frailty score...