Meningioma
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | DIS-MENINGIOMA |
|---|---|
| Type | Disease |
| Aliases | WHO grade I/II/III meningiomaanaplastic meningiomaatypical meningiomaintracranial meningiomaspinal meningiomaМенінгіома |
| Status | reviewed 2026-05-04 | pending_clinical_signoff |
| Diseases | None declared |
| Sources | SRC-EANO-MENINGIOMA-2024 SRC-NCCN-CNS-2025 |
Informational support. All recommendations must be verified by a qualified oncologist. Engineering checks are not clinical validation or treatment approval.
| icd_o_3_morphology | 9530/0 |
|---|---|
| icd_o_3_topography | ["C70"] |
| icd_10 | D32 |
| who_classification | WHO Classification of Tumours of the CNS 5th ed (2021): Meningioma (grades 1–3) |
Notes
Most meningiomas are WHO grade I (benign) and cured by gross total resection. Grade II (atypical) and grade III (anaplastic) have high recurrence rates and limited systemic options. NF2 loss is the most common molecular event; NF2-associated meningiomas often harbor co-occurring SMARCB1/SMARCA4 alterations in aggressive subtypes. Targeted therapy: AKT1-mutant meningioma → AKT inhibitors (capivasertib, ipatasertib) in phase II trials. SMO-mutant meningioma → vismodegib (case series). Selumetinib for NF2-associated plexiform neurofibroma has shown activity (FDA-approved in NF1 pediatric context) but NF2-meningioma selumetinib data is limited. Hormonal agents (progesterone receptor antagonists) not proven effective in trials. Bevacizumab used off-label for recurrent/progressive grade II-III based on small trials.
Used By
Actionability
BMA-NF2-GERMLINE-VESTIBULAR-SCHWANNOMA- NF2 germline pathogenic variants drive Neurofibromatosis Type 2 (NF2 / NF2- related schwa...BMA-NF2-MENINGIOMA- NF2 loss is the most common molecular driver in meningioma (~50% of grade I; higher propo...
Algorithms
ALGO-MENINGIOMA-1L- ALGO-MENINGIOMA-1L
Indication
IND-MENINGIOMA-1L-RESECTION-RT- IND-MENINGIOMA-1L-RESECTION-RTIND-NF2-CARRIER-SURVEILLANCE- IND-NF2-CARRIER-SURVEILLANCE
Procedures
SUR-MENINGIOMA-RESECTION- Maximal safe meningioma resection
Questionnaires
QUEST-MENINGIOMA-1L-STUB- Meningioma — first line
Red flag
RF-NF2-SCHWANNOMATOSIS-CARRIER- Confirmed germline pathogenic / likely-pathogenic variant in NF2 (neurofibromin 2 / merli...RF-WERNER-CONFIRMED-CARRIER- Confirmed biallelic germline pathogenic / likely-pathogenic variants in WRN (RECQL2; Wern...