MGMT promoter methylation status
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | BIO-MGMT-METHYLATION |
|---|---|
| Type | Biomarker |
| Aliases | MGMT methylationO6-methylguanine-DNA methyltransferase methylationСтатус метилювання промотора MGMT |
| Status | reviewed 2026-04-26 |
| Diseases | None declared |
| Sources | SRC-EANO-GBM-2024 SRC-NCCN-CNS-2025 |
Biomarker Facts
| Biomarker type | methylation |
|---|---|
| Measurement | MethodMethylation-specific PCR (MSP) OR pyrosequencing OR methylation-array (450K/EPIC) Unitscategorical: methylated | unmethylated |
| Related biomarkers | None declared |
Used By
Actionability
BMA-MGMT-METHYLATION-GBM- MGMT promoter methylation in IDH-WT glioblastoma is the strongest validated predictor of...
Biomarker
BIO-IDH1-R132C- IDH1 R132C mutation (glioma / cholangiocarcinoma / AML)BIO-IDH1-R132G- IDH1 R132G mutation (glioma / AML)BIO-IDH1-R132H- IDH1 R132H mutation (glioma / AML)
Diseases
DIS-GLIOMA-LOW-GRADE- Low-grade glioma (LGG, WHO grade 2 — IDH-mutant)
Indications
IND-GBM-NEWLY-DIAGNOSED-ELDERLY-TMZ- IND-GBM-NEWLY-DIAGNOSED-ELDERLY-TMZIND-GBM-NEWLY-DIAGNOSED-STUPP- IND-GBM-NEWLY-DIAGNOSED-STUPP
Questionnaires
QUEST-GBM-1L-STUB- Glioblastoma — first line