CD23 expression by IHC / flow cytometry

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`BIO-CD23-IHC`
Type	Biomarker
Aliases	CD23 expressionЕкспресія CD23 (ІГХ / проточна цитометрія)
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	None declared
Sources	`SRC-NCCN-BCELL-2025`

Biomarker Facts

Biomarker type	protein_expression_ihc
Measurement	MethodIHC OR flow cytometry Unitscategorical (positive \| negative)
Related biomarkers	`BIO-CD5-IHC` `BIO-CCND1-IHC`

Notes

Defining differentiator between CLL (CD23+) and MCL (CD23−) when both are CD5+ B-cell. Always interpreted with CD5 + cyclin D1: CLL = CD5+ CD23+ cyclin D1−; MCL = CD5+ CD23− cyclin D1+. Diagnostic not algorithm-driving.

Used By

Biomarker

BIO-CD5-IHC - CD5 expression by IHC / flow cytometry

Indications

IND-CLL-1L-BTKI - IND-CLL-1L-BTKI
IND-CLL-1L-VENO - IND-CLL-1L-VENO
IND-CLL-1L-ZANUBRUTINIB - IND-CLL-1L-ZANUBRUTINIB