TP53 hotspot mutation in MM — high-risk genetic feature; quadruplet (D-VRd) preferred; CA...
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | BMA-TP53-R175H-MM |
|---|---|
| Type | Actionability |
| Status | reviewed 2026-04-27 | pending_clinical_signoff | actionability review required |
| Diseases | DIS-MM |
| Sources | SRC-CIVIC SRC-ESMO-MM-2023 SRC-NCCN-MM-2025 |
Actionability Facts
| Biomarker | BIO-TP53-MUTATION |
|---|---|
| Variant | R175H |
| Disease | DIS-MM |
| ESCAT tier | IIA |
| Recommended combinations | D-VRd, Dara-Rd, ide-cel / cilta-cel |
| Evidence summary | TP53 hotspot mutation in MM — high-risk genetic feature; quadruplet (D-VRd) preferred; CAR-T effective. Hotspot R175H is among the most frequent DBD missense — gain-of-function dominant-negative behavior in some functional assays. |
Notes
ESCAT IIA. Hotspot R175H listed under BIO-TP53-MUTATION (gene-level BIO; no per-hotspot BIO entity).
Used By
No reverse references found in the YAML corpus.