KRAS G12D is the most common PDAC driver (~35-40%). MRTX1133 (Mirati/Bristol) and RMC-980...
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | BMA-KRAS-G12D-PDAC |
|---|---|
| Type | Actionability |
| Status | reviewed 2026-04-27 | pending_clinical_signoff | actionability review required |
| Diseases | DIS-PDAC |
| Sources | SRC-CIVIC SRC-NCCN-PANCREATIC-2025 |
Actionability Facts
| Biomarker | BIO-RAS-MUTATION |
|---|---|
| Variant | KRAS G12D |
| Disease | DIS-PDAC |
| ESCAT tier | IIB |
| Evidence summary | KRAS G12D is the most common PDAC driver (~35-40%). MRTX1133 (Mirati/Bristol) and RMC-9805 are in clinical development; ASTX295 / BI-2865 also active. No FDA approval yet (2026); NCCN flags clinical trial. |
Notes
ESCAT IIB. Encoded under BIO-RAS-MUTATION (no variant-specific BIO for KRAS G12D yet). FLAG: dedicated BIO-KRAS-G12D would improve granularity.
Used By
No reverse references found in the YAML corpus.