CCND1 (cyclin D1) overexpression in MM strongly correlates with t(11;14) and BCL2 depende...
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | BMA-CCND1-IHC-MM |
|---|---|
| Type | Actionability |
| Status | reviewed 2026-04-27 | pending_clinical_signoff | actionability review required |
| Diseases | DIS-MM |
| Sources | SRC-NCCN-MM-2025 |
Actionability Facts
| Biomarker | BIO-CCND1-IHC |
|---|---|
| Variant | CCND1 expression / cyclin D1 IHC (often surrogate for t(11;14)) |
| Disease | DIS-MM |
| ESCAT tier | IIA |
| Recommended combinations | venetoclax + dexamethasone (off-label, t(11;14)-surrogate) |
| Evidence summary | CCND1 (cyclin D1) overexpression in MM strongly correlates with t(11;14) and BCL2 dependence — predicts venetoclax response. Used as surrogate when FISH unavailable. |
Notes
ESCAT IIA. Use FISH t(11;14) when available; CCND1 IHC as surrogate.
Used By
No reverse references found in the YAML corpus.