Cyclin D1 IHC is a defining diagnostic marker of MCL (positive in >95%; SOX11 used in cyc...
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | BMA-CCND1-IHC-MCL |
|---|---|
| Type | Actionability |
| Status | reviewed 2026-04-27 | pending_clinical_signoff | actionability review required |
| Diseases | DIS-MCL |
| Sources | SRC-CIVIC SRC-ESMO-MCL-2024 SRC-NCCN-BCELL-2025 |
Actionability Facts
| Biomarker | BIO-CCND1-IHC |
|---|---|
| Variant | cyclin D1 IHC (universal in MCL; defines diagnosis with t(11;14) FISH) |
| Disease | DIS-MCL |
| ESCAT tier | IA |
| Recommended combinations | per DIS-MCL algorithm (BTKi-centric) |
| Evidence summary | Cyclin D1 IHC is a defining diagnostic marker of MCL (positive in >95%; SOX11 used in cyclin D1-negative variant). Drives DIS-MCL diagnosis but does not 'select' therapy independently of t(11;14). |
Notes
ESCAT IA — disease-defining diagnostic.
Used By
No reverse references found in the YAML corpus.