Onco Wiki / drapeau rouge

Parité élevée (≥5 grossesses à terme) agissant de façon synergique avec l'infection par le VPH pour inf...

Vue déterministe de l'entité source de la LJAM. L'autorité clinique demeure avec les ID de la source cités et l'état d'approbation de l ́examinateur.

IDRF-REPRODUCTIVE-HIGH-PARITY-CERVICAL-PREVENTION
TypeSignal d’alerte
Étatreviewed 2026-05-19 | pending_clinical_signoff
MaladiesDIS-CERVICAL
SourcesSRC-NCCN-CERVICAL-2025 SRC-USPSTF-CERVICAL-2018

Origine du drapeau rouge

DéfinitionHigh parity (≥5 full-term pregnancies) acting synergistically with HPV infection to increase cervical cancer risk approximately 2- to 4-fold versus nulliparous HPV-positive women (IARC multi-centre pooled case-control studies; Muñoz et al. Lancet 2002). Hypothesized mechanisms: hormonal exposure (high parity prolongs estrogen + progesterone exposure), maintenance of the transformation zone on the ectocervix (more accessible to HPV), traumatic effects of repeated vaginal delivery, immunosuppression of pregnancy. Important in low-resource settings where HPV vaccination coverage is incomplete and cervical screening infrastructure is limited (sub-Saharan Africa, parts of South Asia, rural Latin America). In well-screened HPV- vaccinated populations the residual contribution is modest. Prevention- persona RedFlag (§20 v0.3 reproductive expansion).
Direction cliniqueenquêter
Catégorieautres

Logique de déclenchement

{
  "any_of": [
    {
      "finding": "parity_ge_5_full_term",
      "value": true
    },
    {
      "finding": "high_parity_with_hpv_positive",
      "value": true
    }
  ],
  "type": "lab_value"
}

Notes

Prevention-persona RedFlag for high-parity cervical risk amplifier in HPV-positive women. Counseling: adherence to cervical screening per USPSTF/WHO age-and-method schedule; catch-up HPV vaccination through age 45 per ACIP shared-decision; smoking cessation (synergistic risk). STUB pending two-Co-Lead signoff per CHARTER §6.1 dev-mode.

Utilisé par

Indication