Infection active ou latente nécessitant une résolution / prophylaxie avant d'amor...

Vue déterministe de l'entité source de la LJAM. L'autorité clinique demeure avec les ID de la source cités et l'état d'approbation de l ́examinateur.

ID	`RF-RCC-INFECTION-SCREENING`
Type	Signal d’alerte
État	reviewed 2026-04-27 \| pending_clinical_signoff
Maladies	`DIS-RCC`
Sources	`SRC-ESMO-RCC-2024` `SRC-NCCN-KIDNEY-2025`

Origine du drapeau rouge

Définition	Active or latent infection requiring resolution / prophylaxis before initiating ICI doublet (nivo+ipi) or ICI+TKI (axi+pembro, cabo+nivo, len+pembro) in advanced RCC: HBsAg+ or anti-HBc+ (HBV reactivation on ICI), HCV-RNA+ (DAA coordination), HIV+ (ICI safe with virologic suppression), active TB, or active uncontrolled infection.
Direction clinique	en attente
Catégorie	dépistage des infections

Logique de déclenchement

{
  "any_of": [
    {
      "finding": "hbsag",
      "value": "positive"
    },
    {
      "finding": "anti_hbc_total",
      "value": "positive"
    },
    {
      "finding": "hcv_rna",
      "value": "positive"
    },
    {
      "finding": "hiv_status",
      "value": "positive"
    },
    {
      "finding": "active_tb",
      "value": true
    },
    {
      "finding": "active_uncontrolled_infection",
      "value": true
    }
  ],
  "type": "composite"
}

Notes

ICI + chronic HBV: HBsAg+ → entecavir or tenofovir from before first ICI dose through ≥6 months post-last-dose; monitor HBV DNA q3mo. Anti-HBc+ alone (resolved HBV): monitor HBV DNA + ALT q3mo, prophylaxis only if reactivation. HCV-RNA+: prefer SVR before ICI if feasible; DAA can run concurrently with TKI but watch drug-drug interactions (esp. cabozantinib + protease-inhibitor DAA). HIV+ with CD4 >100 + viral load suppressed: ICI active and tolerable. Direction "hold" surfaces a workup-prerequisite annotation rather than switching indication.

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