HRD-positif (mutilation BRCA1/2 OU score d'instabilité génomique ≥42) ovaria séreuse de haute...

Vue déterministe de l'entité source de la LJAM. L'autorité clinique demeure avec les ID de la source cités et l'état d'approbation de l ́examinateur.

ID	`RF-OVARIAN-HRD-ACTIONABILITY`
Type	Signal d’alerte
État	reviewed 2026-04-26 \| pending_clinical_signoff
Maladies	`DIS-OVARIAN`
Sources	`SRC-ESMO-OVARIAN-2024` `SRC-NCCN-OVARIAN-2025`

Origine du drapeau rouge

Définition	HRD-positive (BRCA1/2 mutation OR Genomic Instability Score ≥42) high-grade serous ovarian carcinoma. Treatment-defining for PARPi maintenance after platinum-based induction. Olaparib (SOLO-1 BRCA-only, PAOLA-1 with bev) + niraparib (PRIMA all-comer) substantially improve PFS in HRD-positive subset.
Direction clinique	intensifier
Catégorie	high-risk-biology
Algorithme de décalage	ALGO-OVARIAN-ADVANCED-1L

Logique de déclenchement

{
  "any_of": [
    {
      "finding": "hrd_status",
      "value": "HRD-positive"
    },
    {
      "finding": "brca1_brca2_pathogenic",
      "value": true
    }
  ],
  "type": "biomarker"
}

Notes

HRD testing on FFPE tumor + paired germline. Reflex BRCA → if WT, proceed to GIS scoring. SOLO-1: BRCA-mut maintenance olaparib mPFS 56 vs 14 mo. PAOLA-1: HRD-positive (BRCA-mut OR GIS+) bev+olap mPFS 37 vs 22 mo. PRIMA: niraparib all-comer maintenance benefit weighted toward HRD+ subset.

Utilisé par

Algorithmes

ALGO-OVARIAN-2L - ALGO-OVARIAN-2L
ALGO-OVARIAN-ADVANCED-1L - ALGO-OVARIAN-ADVANCED-1L

Chapitres du manuel

HB-OVARIAN-MAINTENANCE-1L - Advanced ovarian cancer: HRD/BRCA first-line maintenance reasoning

Questions du manuel

HQ-OVARIAN-MAINTENANCE-1L-003 - HQ-OVARIAN-MAINTENANCE-1L-003

Signal d’alerte

RF-OVARIAN-BRCA-MUT-ACTIONABLE - Variante pathogène BRCA1 ou BRCA2 (germline OU somatique) dans les carc...
RF-OVARIAN-HRD-POSITIVE-ACTIONABLE - Homologous Recombination Deficiency (HRD)-positive high-grade serous ovarian carcinoma (B...