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Exposition professionnelle historique documentée au formaldéhyde (HCHO gazeux et aqueux pour...

Vue déterministe de l'entité source de la LJAM. L'autorité clinique demeure avec les ID de la source cités et l'état d'approbation de l ́examinateur.

IDRF-OCC-FORMALDEHYDE-PREVENTION
TypeSignal d’alerte
Étatreviewed 2026-05-18 | pending_clinical_signoff
MaladiesDIS-AML DIS-HNSCC
SourcesSRC-NCCN-AML-2025 SRC-NCCN-BCELL-2025

Origine du drapeau rouge

DéfinitionDocumented historical occupational exposure to formaldehyde (gaseous HCHO and aqueous formalin) — typical high-risk occupations include anatomical pathologists, autopsy technicians, embalmers / funeral- service workers, histology laboratory personnel, particleboard / plywood / MDF manufacturing workers, textile / garment workers handling formaldehyde-treated fabrics, and resin / plastics industry workers — in an individual without a current formaldehyde-associated malignancy diagnosis. Formaldehyde is an IARC Group 1 carcinogen (Monograph 100F, 2012) — established etiologic driver of nasopharyngeal carcinoma (primary endpoint) and myeloid leukemia (AML; sinonasal cancer is also Group-1-associated). Latency from first exposure to nasopharyngeal carcinoma is typically 20-40 years; latency to AML is shorter (5-15 years). There is NO curative intervention for prior exposure — exposure cessa...
Direction cliniqueenquêter
Catégorieautres

Logique de déclenchement

{
  "any_of": [
    {
      "finding": "occupational_formaldehyde_exposure_documented",
      "value": true
    },
    {
      "finding": "occupational_formaldehyde_exposure_years_ge_10",
      "value": true
    }
  ],
  "type": "lab_value"
}

Notes

Prevention-persona RedFlag — v0.3 occupational batch-2 pilot. Fires when patient profile carries documented prior occupational formaldehyde exposure AND no confirmed formaldehyde-attributable malignancy diagnosis. Engine routes to 2-track PreventionPlan: (a) IND-OCC-FORMALDEHYDE-PREVENTION-INTENSIFIED-SURVEILLANCE (standard) — CBC q1y for leukemia surveillance; ENT symptom- awareness counseling (epistaxis, unilateral nasal obstruction, recurrent sinusitis, anosmia) with low-threshold ENT referral if symptoms develop; PPE counseling if active exposure persists. (b) IND-OCC-FORMALDEHYDE-PREVENTION-OBSERVATION (surveillance) — routine general-population care; patient declines structured CBC + ENT surveillance. Trigger findings are computed booleans from occupational-history intake at the patient-profile layer. Evidence base: IARC Monograph 100F (2012); Hauptmann et al. 2009 (NCI formaldehyde-exposed industry cohort — nasopharyngeal + leukemia excess); Beane Freeman et al. 2009 (NCI mortality follow-up). Nasopharyngeal RR ~1.8-2.1 in high-exposure cohorts; AML RR ~1.3-2.0. Sources TODO: IARC Monograph 100F (2012) as a new SRC entity. v0.3 source-authoring backlog. STUB pending two-Cli...

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