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Active or unmanaged infection requiring resolution before initiating cisplatin-based chem...

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IDRF-CERVICAL-INFECTION-SCREENING
TypeSignal d’alerte
Étatreviewed 2026-04-27 | pending_clinical_signoff
MaladiesDIS-CERVICAL
SourcesSRC-ESMO-CERVICAL-2024 SRC-NCCN-CERVICAL-2025

Origine du drapeau rouge

DéfinitionActive or unmanaged infection requiring resolution before initiating cisplatin-based chemoradiation in cervical cancer: HIV-positive (HPV-driven disease — almost universal HIV testing recommended; CD4 informs cisplatin dosing and pelvic-RT field tolerance), HBV-positive (reactivation risk on prolonged chemoradiation), active pelvic abscess / pyometra (must drain before RT), or active TB.
Direction cliniqueen attente
Catégoriedépistage des infections

Logique de déclenchement

{
  "any_of": [
    {
      "finding": "hiv_status",
      "value": "positive"
    },
    {
      "finding": "hbsag",
      "value": "positive"
    },
    {
      "finding": "active_pelvic_infection",
      "value": true
    },
    {
      "finding": "active_tb",
      "value": true
    }
  ],
  "type": "lab_value"
}

Notes

HIV testing recommended for all cervical cancer patients per NCCN (HPV / HIV co-infection extremely common). HIV+ patients tolerate cisplatin-CRT with ART optimization; CD4 <200 is relative contraindication — coordinate with HIV clinic. HBV+: entecavir/tenofovir prophylaxis during prolonged chemo phases. Pelvic abscess / pyometra: percutaneous drainage / antibiotics first; RT into infected field worsens necrosis. This RF surfaces workup-prerequisites; engine does not switch indication.

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Indication