Emtricitabine / Tenofovir disoproxil fumarate (HIV pre-exposure prophylaxis)
Vue déterministe de l'entité source de la LJAM. L'autorité clinique demeure avec les ID de la source cités et l'état d'approbation de l ́examinateur.
| ID | DRUG-EMTRICITABINE-TENOFOVIR-DF-PREP |
|---|---|
| Type | Médicament |
| Alias | Emtricitabine / Tenofovir DF (PrEP VIH)F/TDFFTC/TDFTrévadaTruvada PrEPЕмтрицитабін / Тенофовіру дизопроксил фумарат (PrEP — преекспозиційна профілактика ВІЛ) |
| État | examinés 2026-05-18 |
| Maladies | Aucune déclaration |
| Sources | SRC-AASLD-HBV-2024 SRC-NIH-AIDS-2024 |
Faits sur les drogues
| Catégorie | Combinaison à dose fixe à deux IRNT — prophylaxie pré-exposition du VIH-1 (PrEP) |
|---|---|
| Mécanisme | Fixed-dose combination of two nucleoside / nucleotide reverse- transcriptase inhibitors. Emtricitabine (200 mg) is a cytidine-analog NRTI; after intracellular phosphorylation it competitively inhibits HIV-1 reverse transcriptase and terminates chain elongation. Tenofovir disoproxil fumarate (300 mg) is a phosphonate prodrug of tenofovir delivering tenofovir-DP intracellularly, inhibiting HIV-1 RT and HBV polymerase. As ORAL DAILY PrEP in HIV-negative adults at substantial risk, FTC/TDF reduces HIV acquisition by ≥99% with consistent daily adherence (iPrEx 2010, Partners PrEP, TDF2; >90% relative risk reduction at intention-to-treat). Cancer-prevention pathway: preventing incident HIV infection prevents downstream AIDS-defining malignancies (Kaposi sarcoma, NHL incl. PCNSL, invasive cervical cancer) and several HPV-related and viral hepatitis-related cancers driven by HIV-induced immunos... |
| Dose typique | Adult / adolescent (≥35 kg) PrEP: 1 tablet (200 mg FTC / 300 mg TDF) PO once daily, with or without food. Steady-state intracellular tenofovir-DP requires ~7 days of daily dosing (rectal tissue) and ~20 days (cervicovaginal tissue) — establish high adherence BEFORE potential exposure. Event-driven (2-1-1) PrEP — MSM only (IPERGAY 2015, WHO 2019): 2 tablets 2-24 h before sex, 1 tablet 24 h after first dose, 1 tablet 48 h after first dose. NOT recommended for cisgender women, vaginal sex (insufficient tissue levels in cervicovaginal compartment), or PEP indications. HIV-1 treatment (combination ART): 1 tablet PO daily + 3rd agent. Renal adjustment: CrCl 30-49 → q48h; CrCl <30 → AVOID PrEP (in... |
| Ukraine enregistrée | Vrai |
| NSZU remboursé | Faux |
| Ukraine vérifiée pour la dernière fois | 2026-05-18 |
Avertissements
- Exacerbation aiguë sévère de l'hépatite B chez les patients infectés par le VHB après arrêt de la procédure — surveillance des TFT ≥ plusieurs mois après arrêt
- Risk of HIV-1 resistance in HIV-positive individuals using PrEP dose (must confirm HIV-negative status at baseline and every 3 months)
Notes
STUB — v0.2 prevention-workstream authoring (batch 3); pending two- Clinical-Co-Lead signoff per CHARTER §6.1 dev-mode. TRUVADA-FOR-PREP is the original FDA-approved oral PrEP (2012). Two-NRTI fixed-dose combination — daily oral, with or without food. Cancer-prevention rationale: preventing HIV acquisition prevents downstream AIDS-defining cancers (Kaposi sarcoma, NHL incl. PCNSL and Burkitt, invasive cervical cancer) and several non-AIDS-defining cancers (HPV-driven anal, oropharyngeal, hepatocellular, Hodgkin lymphoma) at population level. Distinct entity from DRUG-BICTEGRAVIR-EMTRICITABINE-TENOFOVIR-AF (Biktarvy — HIV treatment only, NOT PrEP) and from DRUG-TENOFOVIR-DF / DRUG-TENOFOVIR-AF (single-agent HBV/HIV-treatment context). Cabotegravir LA (DRUG-CABOTEGRAVIR-LA-PREP, batch 3 sibling) is the long-acting injectable PrEP alternative. Truvada PrEP indications: MSM, transgender women, transgender men, cisgender heterosexual women and men at substantial risk, people who inject drugs. Renal monitoring is the critical safety pillar (baseline CrCl + every 6 months). HIV-status monitoring is the resistance-prevention pillar (every 3 months). HBsAg baseline screen is mandatory — if...
Utilisé par
No reverse references found in the YAML corpus.