Tumeur des cellules granuleuses adultes de l'ovaire
Vue déterministe de l'entité source de la LJAM. L'autorité clinique demeure avec les ID de la source cités et l'état d'approbation de l ́examinateur.
| ID | DIS-GRANULOSA-CELL |
|---|---|
| Type | Maladie |
| Alias | AGCTTumeur des cellules granuleuses adultesOvaire du GCTTCG de type adultetumeur de cellules granuleusesДоросла гранульозоклітинна пухлина яєчника |
| État | reviewed 2026-05-04 | pending_clinical_signoff |
| Maladies | Aucune déclaration |
| Sources | SRC-ESMO-OVARIAN-2024 SRC-NCCN-OVARIAN-2025 |
Informational support. All recommendations must be verified by a qualified oncologist. Engineering checks are not clinical validation or treatment approval.
| icd_o_3_morphology | 8620/3 |
|---|---|
| icd_o_3_topography | ["C56"] |
| icd_10 | C56 |
| who_classification | WHO Classification of Female Genital Tumours 5th ed (2020): Adult granulosa cell tumour |
Notes
Adult GCT is defined molecularly by the FOXL2 p.C134W mutation (present in ~97% of cases), which is the only pathognomonic molecular alteration in any solid tumor. FOXL2 is a granulosa cell transcription factor; the C134W mutation is a dominant-negative gain-of-function that prevents normal granulosa cell differentiation. Clinically, tumors present with estrogen excess (abnormal uterine bleeding, endometrial pathology) or abdominal mass. Prognosis is generally favorable for stage I (90% 10-yr OS) but late recurrences (10–20 years) are characteristic. No FDA-approved targeted therapy as of 2026; FOXL2 inhibition and CDK4/6 inhibitors are in clinical trials. FOXL2 mutation testing is diagnostic, not therapeutic selection (ESCAT IIB — clinical utility as diagnostic/prognostic marker).
Utilisé par
Pertinence thérapeutique
BMA-FOXL2-GRANULOSA-CELL- FOXL2 p.C134W (c.402C>G) est le marqueur moléculaire définissant la tumeur des cellules granuleuses adultes (...
Algorithmes
ALGO-GRANULOSA-CELL-1L- ALGO-GRANULOSA-CELL-1L
Maladie
DIS-SERTOLI-LEYDIG-OVARIAN- Tumeur des cellules Sertoli-Leydig de l'ovaire
Indication
IND-GRANULOSA-CELL-1L-CARBOPLATIN-PACLITAXEL- IND-GRANULOSA-CELL-1L-CARBOPLATIN-PACLITAXEL
Questionnaires
QUEST-GRANULOSA-CELL-1L-STUB- Tumeur des cellules granuleuses adultes — première ligne