Charge virale de l'ADN-EBV (PCR quantitative, plasma)

Vue déterministe de l'entité source de la LJAM. L'autorité clinique demeure avec les ID de la source cités et l'état d'approbation de l ́examinateur.

ID	`BIO-EBV-DNA`
Type	Biomarqueur
Alias	PCR EBVCharge virale EBVCharge quantitative de l'ADN EBVL'ADN EBV plasmatiqueВірусне навантаження EBV-DNA (кількісна ПЛР, плазма)
État	reviewed 2026-04-26 \| pending_clinical_signoff
Maladies	`DIS-NK-T-NASAL` `DIS-NPC` `DIS-PTLD`
Sources	`SRC-NCCN-BCELL-2025`

Données biomarqueurs

Type de biomarqueur	viral_load
Mesure	MéthodeReal-time quantitative PCR for EBV-DNA on cell-free plasma (preferred) or whole blood. Plasma EBV-DNA reflects active viral replication and tumor lysis; whole-blood EBV-DNA includes latent virus in B-cells and is less specific for active disease. Standardized in IU/mL via WHO international standard. UnitésUI/ml (ou copies/ml avec conversion spécifique au test) Échelle type 0 100000000
Biomarqueurs connexes	`BIO-EBV-STATUS` `BIO-HIV-STATUS`

Notes

Companion to BIO-EBV-STATUS (qualitative tissue EBER-ISH). EBV-DNA is the *quantitative* serum marker used for: - **Extranodal NK/T nasal-type lymphoma**: pre-treatment baseline; monitoring during SMILE / DDGP / asparaginase-based regimens; post-treatment surveillance. Rising EBV-DNA on therapy correlates with poor response; persistent post-treatment positivity predicts relapse. - **PTLD**: EBV-driven PTLD shows EBV-DNA load decrease with rituximab + reduced immunosuppression; trend is response surrogate. - **HIV-associated EBV+ DLBCL / plasmablastic / primary effusion**: contextual; not standardly used for treatment decisions. - **Post-HSCT monitoring**: weekly EBV-DNA used to detect early PTLD risk; preemptive rituximab if doubling. Wired into: ALGO-NK-T-NASAL-1L (notes only — full Monitoring entity with thresholds and frequency to be authored). reviewer_signoffs: 0 # STUB — pending two Clinical Co-Lead approvals

Utilisé par

Maladie

DIS-NPC - Carcinome nasopharyngé (NPC)

Indication

IND-NK-T-NASAL-1L-P-GEMOX - IND-NK-T-NASAL-1L-P-GEMOX
IND-NK-T-NASAL-1L-SMILE - IND-NK-T-NASAL-1L-SMILE
IND-NPC-1L-LOCALLY-ADVANCED-CCRT - IND-NPC-1L-LOCALLY-ADVANCED-CCRT
IND-NPC-1L-METASTATIC-GC-PD1 - IND-NPC-1L-METASTATIC-GC-PD1
IND-PTLD-1L-REDUCE-IS - IND-PTLD-1L-REDUCE-IS

Questionnaires

QUEST-NK-T-NASAL-1L-STUB - Lymphome extranodal NK/T-Cell, type nasal — première ligne
QUEST-PTLD-1L-STUB - Trouble lymphoprolifératif post-transplantation — première ligne

Signal d’alerte

RF-NPC-EBV-DNA-POST-TREATMENT-SURVEILLANCE - EBV-DNA plasmatique détectable ou en hausse (BIO-EBV-DNA, PCR quantitatif) après achèvement de d...

Sources

SRC-EBV-DNA-NPC-LIN-2004 - Quantification de l'ADN plasmatique du virus Epstein-Barr chez des patients...