BCL6 IHC (expression des protéines)
Vue déterministe de l'entité source de la LJAM. L'autorité clinique demeure avec les ID de la source cités et l'état d'approbation de l ́examinateur.
| ID | BIO-BCL6-IHC |
|---|---|
| Type | Biomarqueur |
| Alias | Lymphome des cellules B 6BCL-6 IHCBCL6 immunohistochimieProtéine BCL6 |
| État | reviewed 2026-05-05 | pending_clinical_signoff |
| Maladies | Aucune déclaration |
| Sources | SRC-NCCN-BCELL-2025 |
Données biomarqueurs
| Type de biomarqueur | protein_expression_ihc |
|---|---|
| Détails de la mutation | {"gene_id_ncbi": 604, "gene_symbol": "BCL6", "note": "BCL6 is a transcriptional repressor essential for germinal center (GC) B-cell development. BCL6 IHC detects nuclear protein expression (not rearrangement). Positive = nuclear staining. Threshold: >30% nuclear positivity typically used as cut-off for GC-origin classification (Hans algorithm). Note: BIO-BCL6-REARRANGEMENT is a distinct biomarker (chromosomal translocation detected by FISH) — different from BCL6 protein expression by IHC.\n"} |
| Mesure | MéthodeIHC sur biopsie FFPE. Anticorps anti-BCL6 (clone PG-B6p). Teinture nucléaire notée en % cellules tumorales positives. seuil de l'algorithme Hans : >30% noyau positif = BCL6+. |
| Biomarqueurs connexes | BIO-CD10-IHC BIO-MUM1-IHC BIO-DLBCL-COO-HANS BIO-BCL6-REARRANGEMENT BIO-MYC-REARRANGEMENT |
Notes
BCL6 IHC is a core component of the Hans algorithm for DLBCL cell-of-origin classification. While gene expression profiling (GEP, Lymph2Cx assay) is the reference standard for GCB/ABC classification, Hans IHC is widely used in resource-limited settings (concordance with GEP ~80%). BCL6 protein expression is distinct from BCL6 chromosomal rearrangement (t(3;v) translocations detected by FISH) — both exist independently. BCL6 rearrangement occurs in ~25-35% of DLBCL and may be present in either GCB or non-GCB subtypes.
Utilisé par
Biomarqueur
BIO-CD10-IHC- CD10 IHC (CALLA, néprilysine)BIO-MUM1-IHC- MUM1/IRF4 IHC (Myélome multiple oncogène 1)