Phenoxybenzamine
Vista determinista de la entidad fuente YAML. La autoridad clínica sigue con los ID de fuente citados y estado de firma del revisor.
| ID | DRUG-PHENOXYBENZAMINE |
|---|---|
| Tipo | Fármaco |
| Aliaces | Dibenzilinanon-selective irreversible alpha blockerФеноксибензамін |
| Situación | reviewed 2026-07-11 | pending_clinical_signoff |
| Enfermedades | DIS-PHEOCHROMOCYTOMA |
| Fuentes | SRC-ENDOCRINE-SOCIETY-PPGL-2014 SRC-NCCN-NET-2025 |
Datos sobre drogas
| Clase | Non-selective, irreversible alpha-1/alpha-2 adrenergic receptor antagonist |
|---|---|
| Mecanismo | Covalently and irreversibly binds alpha-1 and alpha-2 adrenergic receptors, producing a long-acting, non-competitive blockade of catecholamine-mediated vasoconstriction. In pheochromocytoma / paraganglioma (PPGL), preoperative alpha-blockade with phenoxybenzamine (or a selective alpha-1 blocker such as doxazosin) is mandatory before surgery to prevent an intraoperative hypertensive crisis from catecholamine release during tumor manipulation (Endocrine Society 2014 PPGL guideline). Alpha-2 blockade component can cause reflex tachycardia and orthostatic hypotension, which is more pronounced than with selective alpha-1 agents. |
| Dosificación típica | Starting dose typically 10 mg PO BID, titrated upward in 10-20 mg/day increments every few days to achieve blood-pressure normalization and resolution of orthostatic/paroxysmal symptoms, per Endocrine Society 2014 PPGL guideline (SRC-ENDOCRINE-SOCIETY-PPGL-2014); usual preoperative course runs roughly one to two weeks before surgery to allow adequate, sustained alpha-blockade and intravascular volume re-expansion. Exact target BP/HR thresholds and final maintenance dose are individualized by the treating team and are NOT fixed numeric values in this stub -- see RF-PHEO-INADEQUATE-ALPHA-BLOCKADE for the hard sequencing gate this drug exists to satisfy. |
| Ucrania registrada | Falso |
| NSZU reembolsado | Falso |
| Ucrania verificada por última vez | 2026-07-11 |
Notas
Históricamente el agente preferido por las pautas para el bloqueo alfa de la GPP preoperatorio, ya que su bloqueo irreversible de acción prolongada es más difícil de superar con el aumento de la catecolamina durante el manejo del tumor; la doxazosina (bloqueante alfa-1 selectivo y reversible; véase DRUG-DOXAZOSIN) es una alternativa ampliamente utilizada, más disponible y mejor tolerada con menos taquicardia reflexiva -- la elección entre ambos es por práctica/disponibilidad local, no modelada como preferencia de nivel KB. STUB pendiente de firma clínica co-lead (CARTER §6.1, exento de modo dev).
Utilizado por
Fármaco
DRUG-DOXAZOSIN- Doxazosin
Esquema terapéutico
REG-ALPHA-BLOCKADE-PREOP-PHEO- bloqueo alfa-adrenérgico preoperatorio (phenoxybenzamine, antes del feocromocitoma/paragán...