Carcinoma de células escamosas del pene
Vista determinista de la entidad fuente YAML. La autoridad clínica sigue con los ID de fuente citados y estado de firma del revisor.
| ID | DIS-PENILE-SCC |
|---|---|
| Tipo | Enfermedad |
| Aliaces | Cáncer del peneCSC del pene asociado con el VPHEl CSC del peneCáncer del peneПлоскоклітинна карцинома пенісу |
| Situación | reviewed 2026-05-18 | pending_clinical_signoff |
| Enfermedades | Ninguna declarada |
| Fuentes | SRC-IARC-MONO-100B-2012 SRC-NCCN-BLADDER-2025 |
Informational support. All recommendations must be verified by a qualified oncologist. Engineering checks are not clinical validation or treatment approval.
| icd_o_3_morphology | 8070/3 |
|---|---|
| icd_o_3_topography | ["C60"] |
| icd_10 | C60 |
| who_classification | WHO Urinary and Male Genital Tumours 5th ed (2022): Penile squamous cell carcinoma (HPV-associated + HPV-independent subtypes) |
Notas
Two biological subgroups (HPV-driven vs HPV-independent) managed similarly anatomically. Treatment: early-stage (Tis, Ta, T1a) — organ-sparing approaches (topical 5-FU / imiquimod for Tis; CO2- laser or wide local excision for T1a; glansectomy for selected T2); advanced primary (T2-T4) — partial / total penectomy; inguinal nodal management — dynamic sentinel node biopsy or modified inguinal lymphadenectomy per cN0 vs cN+ status (highly morbid, complications common); metastatic — cisplatin + 5-FU OR TIP (paclitaxel + ifosfamide + cisplatin) per EAU; pembrolizumab in MSI-H subset. HPV vaccination of boys (Gardasil-9) is the primary prevention modality alongside neonatal circumcision discussion.
Utilizado por
Algoritmos
ALGO-PENILE-SCC-1L- ALGO-PENILE-SCC-1L
Fármaco
DRUG-IMIQUIMOD- Imiquimod.
Indicación
IND-PENILE-SCC-1L-ORGAN-SPARING- IND-PENILE-SCC-1L-ORGAN-SPARINGIND-PENILE-SCC-1L-PENECTOMY-NODAL- IND-PENILE-SCC-1L-PENECTOMY-NODALIND-PENILE-SCC-METASTATIC-1L-CISPLATIN-5FU- IND-PENILE-SCC-METASTATIC-1L-CISPLATIN-5FUIND-PENILE-SCC-METASTATIC-1L-MSI-H-PEMBRO- IND-PENILE-SCC-METASTATIC-1L-MSI-H-PEMBROIND-PENILE-SCC-METASTATIC-1L-TIP- IND-PENILE-SCC-METASTATIC-1L-TIP
Señal de alerta
RF-PENILE-SCC-MSI-H-ACTIONABILITY- Carcinoma de células escamosas del pene MSI-alto / dMMR — un subs...
Esquema terapéutico
REG-CISPLATIN-5FU-PENILE- Cisplatin + 5-fluorouracil (metastatic penile SCC, 1L)REG-TIP-PENILE- TIP (paclitaxel + ifosfamide + cisplatin, pene SCC)
Fuentes
SRC-EAU-PENILE-2024- Cáncer de pene de la UAE