Tumor de células granulosas adultas del ovario

Vista determinista de la entidad fuente YAML. La autoridad clínica sigue con los ID de fuente citados y estado de firma del revisor.

ID	`DIS-GRANULOSA-CELL`
Tipo	Enfermedad
Aliaces	AGCTTumor de células granulosas adultasOvario del GCTECG de tipo adultotumor de células granulosasДоросла гранульозоклітинна пухлина яєчника
Situación	reviewed 2026-05-04 \| pending_clinical_signoff
Enfermedades	Ninguna declarada
Fuentes	`SRC-ESMO-OVARIAN-2024` `SRC-NCCN-OVARIAN-2025`

Informational support. All recommendations must be verified by a qualified oncologist. Engineering checks are not clinical validation or treatment approval.

Fuente YAML

icd_o_3_morphology	8620/3
icd_o_3_topography	["C56"]
icd_10	C56
who_classification	WHO Classification of Female Genital Tumours 5th ed (2020): Adult granulosa cell tumour

Capacidades

Notas

Adult GCT is defined molecularly by the FOXL2 p.C134W mutation (present in ~97% of cases), which is the only pathognomonic molecular alteration in any solid tumor. FOXL2 is a granulosa cell transcription factor; the C134W mutation is a dominant-negative gain-of-function that prevents normal granulosa cell differentiation. Clinically, tumors present with estrogen excess (abnormal uterine bleeding, endometrial pathology) or abdominal mass. Prognosis is generally favorable for stage I (90% 10-yr OS) but late recurrences (10–20 years) are characteristic. No FDA-approved targeted therapy as of 2026; FOXL2 inhibition and CDK4/6 inhibitors are in clinical trials. FOXL2 mutation testing is diagnostic, not therapeutic selection (ESCAT IIB — clinical utility as diagnostic/prognostic marker).

Utilizado por

Relevancia terapéutica

BMA-FOXL2-GRANULOSA-CELL - FOXL2 p.C134W (c.402C>G) es el marcador molecular que define...

Algoritmos

ALGO-GRANULOSA-CELL-1L - ALGO-GRANULOSA-CELL-1L

Enfermedad

DIS-SERTOLI-LEYDIG-OVARIAN - Tumor de las células Sertoli-Leydig del ovario

Indicación

IND-GRANULOSA-CELL-1L-CARBOPLATIN-PACLITAXEL - IND-GRANULOSA-CELL-1L-CARBOPLATIN-PACLITAXEL

Cuestionarios

QUEST-GRANULOSA-CELL-1L-STUB - Tumor de células granulosas adultas — primera línea