Mäßige Leberfunktionsstörungen (Child-Pugh B, Punkte 7-9). Auslöset Dosismodifikation oder Sub...

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ID	`RF-ORGAN-HEPATIC-CHILD-PUGH-B`
Art	Warnhinweis
Status	reviewed 2026-04-27 \| pending_clinical_signoff
Erkrankungen	None declared
Quellen	`SRC-AASLD-HCC-2023` `SRC-NCCN-HCC-2025`

Ursprung der Roten Flagge

Begriffsbestimmung	Moderate hepatic dysfunction (Child-Pugh B, score 7-9). Triggers dose modification or substitution for hepatically metabolized drugs: doxorubicin, vincristine, vinblastine, paclitaxel, docetaxel, etoposide, sorafenib, atezolizumab + bevacizumab caution; bilirubin and AST/ALT-driven attenuation per FDA labels.
Klinische Richtung	Eskalation
Kategorie	Organdysfunktion

Logik auslösen

{
  "all_of": [
    {
      "finding": "child_pugh_class",
      "value": "B"
    }
  ],
  "type": "composite_score"
}

Anmerkungen

Child-Pugh B is the most clinically nuanced hepatic-dysfunction tier — many systemic-therapy trials (atezo+bev for HCC, sorafenib) limit to Child-Pugh A or carefully selected B7. Doxorubicin: 50% reduction at bilirubin 1.5-3 mg/dL, 75% at 3-5; vincristine: 50% reduction at bilirubin 1.5-3, hold ≥3; paclitaxel: dose reduction per total bilirubin; etoposide reduce 50% at bilirubin 1.5-3. R-CHOP feasible at Child-Pugh B with vincristine substitution / dose attenuation. Sorafenib safe at Child-Pugh B7 (SHARP subgroup, GIDEON registry); avoid at B8-9. For HCC-specific dosing see RF-HCC-CHILD-PUGH-B-C.

Verwendet von

Algorithmen

ALGO-HCC-SYSTEMIC-1L - ALGO-HCC-SYSTEMIC-1L