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Erwachsene Granulosa-Zelltumor des Eierstocks

Deterministische Ansicht der Quelle YAML Entität. Klinische Autorität bleibt mit den zitierten Quell-IDs und Rezensenten Sign-off Zustand.

Informational support. All recommendations must be verified by a qualified oncologist. Engineering checks are not clinical validation or treatment approval.

Quelle: YAML

Fähigkeiten

Anmerkungen

Adult GCT is defined molecularly by the FOXL2 p.C134W mutation (present in ~97% of cases), which is the only pathognomonic molecular alteration in any solid tumor. FOXL2 is a granulosa cell transcription factor; the C134W mutation is a dominant-negative gain-of-function that prevents normal granulosa cell differentiation. Clinically, tumors present with estrogen excess (abnormal uterine bleeding, endometrial pathology) or abdominal mass. Prognosis is generally favorable for stage I (90% 10-yr OS) but late recurrences (10–20 years) are characteristic. No FDA-approved targeted therapy as of 2026; FOXL2 inhibition and CDK4/6 inhibitors are in clinical trials. FOXL2 mutation testing is diagnostic, not therapeutic selection (ESCAT IIB — clinical utility as diagnostic/prognostic marker).

Verwendet von

Therapeutische Relevanz

• BMA-FOXL2-GRANULOSA-CELL - FOXL2 p.C134W (c.402C>G) ist der bestimmende molekulare Marker des adulten Granulosa-Zelltumors...

Algorithmen

• ALGO-GRANULOSA-CELL-1L - ALGO-GRANULOSA-CELL-1L

Erkrankung

• DIS-SERTOLI-LEYDIG-OVARIAN - Sertoli-Leydig Zelltumor des Eierstocks

Anwendungsgebiet

• IND-GRANULOSA-CELL-1L-CARBOPLATIN-PACLITAXEL - IND-GRANULOSA-CELL-1L-CARBOPLATIN-PACLITAXEL

Fragebogen

• QUEST-GRANULOSA-CELL-1L-STUB - Erwachsene Granulosa-Zelltumor — erste Zeile